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LONGEVITY MEME NEWSLETTERNovember 05 2007The Longevity Meme Newsletter is a weekly e-mail containing news opinions and happenings for people interested in healthy life extension: making use of fast lifestyle choices technology and proven medical advances to be healthy longer lives. To subscribe or unsubscribe from the Longevity Meme Newsletter please visit http://www longevitymeme org/newsletter/______________________________CONTENTS- Recent AGE-Breaker Research- Ending Aging Hits Amazon Top 100- Discussion- Latest Healthy Life Extension HeadlinesRECENT AGE-BREAKER RESEARCHI've noticed an upswing in published investigate into breaking down or inhibiting production of advanced glycation endproducts (AGEs) of late. AGEs are a range of metabolic byproducts that gum up the works in your biochemistry such as by sticking vital chemical compounds together so that they can't perform their role. The more AGEs in your system the worse the damage they cause directly contributing to age-related degeneration and disease:A be of groups are at the re-create of animal or early human trials with designed or discovered compounds many focused on diabetes due to the increased aim of AGEs associated with that condition and the fact that regulatory agencies do not accept aging as a disease - and thus will not approve a therapy designed to repair a cause of aging. For example the AGE-breaker compound C36 has been evaluated on diabetic rats:"Unfortunately past bear witness suggests that excitement over work in rodents should be muted at best - the history of ALT-711 or alagebrium demonstrates that different types of AGEs are important in shorter-lived mammals versus humans. So far promising bring home the bacon in mice and rats has translated poorly into human therapies - in most cases through trying to address the do by AGEs."Some more AGE investigate from the recent past:ENDING AGING HITS AMAZON TOP 100"Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime" briefly made it into the Amazon top 100 best sellers this past week following wider distribution of a Washington Post bind on biomedical gerontologist Aubrey de Grey and the Strategies for Engineered Negligible Senescence (SENS). Great news!"I am encouraged that a hard science book can comfort attract a lot of attention in the marketplace of ideas and pleased that a grounding in the SENS view of how to blackball aging will spread further as a result. The spread and discussion of these ideas is a necessary foundation for the affect of raising significant advance funding for ongoing SENS investigate. Both MitoSENS and LysoSENS projects are funded at present by donations to the Methuselah Foundation but a wide range of other SENS-like or SENS-applicable work takes place out there in the world. We would like to see those research groups change and attain the funding they be."You can find out more about presently ongoing SENS investigate at the Methuselah Foundation website:DISCUSSIONThe highlights and headlines from the past week follow below. If you have comments for us please do send telecommunicate to newsletter@longevitymeme org bequeath - if you desire this newsletter the chances are that your friends will find it useful too. Forward it on or affix a copy to your favorite online communities. Encourage the people you know to fling in and alter a difference to the future of health and longevity!Reasonreason@longevitymeme org______________________________LATEST HEALTHY LIFE EXTENSION HEADLINESTo view commentary on the latest news headlines complete with links and references gratify tour the daily news divide of the Longevity Meme: http://www longevitymeme org/news/A Million Optimizations Without Forethought (November 02 2007)Let us count the ways in which biochemical processes optimized through evolution for youthful health and reproductive success interact poorly as they change with age and thus create pain and suffering. Here is one example of many from EurekAlert!: "Jason Dyck and his investigate team at the University of Alberta undergo been studying the types of fuels used by the heart in young and aged mice. The young healthy heart normally used a balance of fat and sugar to generate energy to allow the heart to beat and pump daub efficiently. However as the heart ages the ability to use fat as an energy source deteriorates. This compromises heart function in the elderly. Interestingly at a time when the heart is using less fat for energy. Dyck has shown that a protein that is responsible for transporting fat into the contractile cells of the heart actually increases. Based on this finding. Dyck proposed that the mismatch between fat uptake and fat use in the heart could lead to an accumulation of fat in the heart resulting in an age-related decrease in heart function." This being the age of biotechnology they go on to engineer a walk that doesn't suffer from this specific problem - but you get the idea. Aging is damage and change that causes disarry; repair or prevent the changes sufficiently well and you don't have to patch up after the disarray. Biomechanisms of Limb Regeneration (November 02 2007)LiveScience reports on progress in understanding how salamander biochemistry regenerates entire lost body parts: scientists "ran experiments in which they chopped off red-spotted newts' limbs and the attached nerves. The nerves are needed to stimulate the production of the nAG protein so the nerve-severing essentially removed the newts' source of nAG. Then they zapped the cells of the now-exposed body region with electrical pulses so they could mouth little bundles of DNA carrying genes for the protein nAG. Within 30 to 40 days the newts had regenerated their lost limbs digits and all. However the new limbs had less go across mass than the original ones. advance lab experiments revealed the nAG protein - a molecule - works directly on the blastema cells causing them to grow and divide. ... It essentially tells us that one single molecule is able to support the proliferation of blastema cells right from the start of regeneration all the way through to the formation of the digits." As the researcher notes it is a solid step but many more steps are required before we humans will be regrowing damaged organs. FuturePundit on the Repair of Aging (November 01 2007)Thoughs from Randall Parker: "Aubrey [de color] believes (and FuturePundit agrees) that we can create biotechnologies that ordain allow us to change aging and make us young again. This goal will be achieved within the lifetimes of at least some of the populate currently alive. The sooner the general public realizes this the faster this goal ordain be realized. ... Aubrey thinks populate are heavily invested in believing that death from aging is inevitable. This position made comprehend back when death from aging really was inevitable. Best to defend that aging is a good thing if there's nothing you can do about it. alter your peace and sight reasons to be happy with what you can't change. But the evaluate of advance of biotechnology is accelerating with DNA sequencers and microfluidic devices becoming more powerful in ways analogous to the rate of develop with computers. We can strive for goals that used to be unattainable. We should start trying to check aging. It is a solvable problem." Exactly right - and we can all jump in and back up. You don't have to be a researcher to help to researchers make faster progress towards the defeat of aging. A Gentle Reminder About the Fat (November 01.

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It should first be noted that many online casinos are licensed in the Caribbean Islands and are providing jobs and economical growth where it is come up needed. Licenses are also available in Africa. Europe and other parts of the world as the consider over legalization regulation and freedom on the Internet is widened. Originally the U. S took a rest opposing online gambling using a law known as the Wire Act to command online casinos. To go out. 18 U. S. C.1084 is still the law most likely to be used in prosecuting casinos. However as legal experts have tried to show the equip Act is riddled with loopholes. In fact invocation of this law has only added to the contention that new legislation is necessary. On walk 19. 1997 the Internet Gambling Prohibition Act better known as the "Kyl bill" was originally introduced. The proposed act would change the federal Interstate Wire Act 18 U. S. C.1084 which forbids interstate gambling by telecommunicate or other wire devices but not the Internet by name. (The equip Act is a law dating back approximately 40 years and predates the Internet and most other modern communications networks.)Senator Kyl's bill threatened to allow the Federal Communications Commission to compel regulations against interstate computer service providers prohibiting the interstate or foreign transmission of gambling information. The FCC could potentially order ISPs to change state down or block access to gambling Web sites change surface if those are based outside the United States. Online casinos assert that they fall under the legislature of their Country of licensing and that U. S law would not affect them. Many doubt the technological ability for governments to insure a blanket ban although a recent initiative in the U. S calls for a ban on the use of credit cards and wire transfers for the purposes of web wagering. Australia had originally positioned itself to create tax revenues through regulation of this hugely profitable industry. The Interactive Gambling (Player Protection) Act was passed by Parliament on March 18. 1998 and commenced on October 1st 1998 but recently there has been a reversal of fortune for casino operators drink Under. After a prolonged moratorium on the spread of online gambling the Australian Senate passed a ban on interactive gaming forcing Australian sites to close their doors and declaring that the public would not be allowed to gamble on the Net. In the U. K. where gambling on sports has long been an accepted part of life for many signs of easing restrictions on Internet gaming are many. Recently The Isle of Man which is part of the United Kingdom but makes many of its own laws opened its doors and began to give licenses to new cyber-gaming ventures. Las Vegas-based casino giant MGM Mirage was one of the first to bear on. Even more sweeping was a relaxation in England's betting tax a move that coincided with the government's decision to woo British operators of large-scale sportsbetting sites back into the motherland thereby keeping countries overseas from collecting massive tax profits from U. K businesspeople. The speak attitude has recently been displayed in the United States where the Wire Act was successfully used to act Jay Cohen former owner a the sports wagering place World Sports transfer. Cohen was sentenced to serve one year and nine months for his activities. His recent challenge to overturn the conviction was upheld by the 2nd U. S. go Court saying that betting was "clearly illegal in New York". No further mention was issued on the legality of hundreds of other sites that offer the same services to U. S bettors. Results show that despite fractured attempts to ban or place tighter controls on Internet gambling more and more people worldwide are wagering online. Expert opinion is that legislation cannot constrain the evaluate of growth taking place in the industry no matter the legal issues involved. Despite efforts to pass a bill in the U. S. Congress many people in America do gamble online. Americans pay US$600 billion a year on gaming every year and even the land-based casinos in Vegas are starting to get in on the challenge. Around the world different countries undergo taken varying stances: In China. Hong Kong passed a bill tightening gambling controls but leaving online gambling alone in recognition that a ban would be unenforceable. The most recent failure of the "Kyl Bill" in the United States to ban online gambling in the measure accommodate of 2000 came as little surprise. There was a race between the states of Nevada and New Jersey to create a framework for the regulation of legal online gambling as the first to do so would gain a competitive advantage over the other. That race looks to have ended when support for online gaming in the New Jersey dwindled. Assembly account 3150 would undergo legalized Internet gambling in New Jersey operated by Atlantic City casinos and played by New Jerseyans. Assemblyman Anthony Impreveduto who wrote the account said legal interpretations.

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and waste every dime you undergo on you and you go out cursing the casino your very existence and the existence of everyone in a circle you. You went to the casino to win and instead you went for broke before you change surface considered leaving and the only reason you are leaving is that you are now b-r-o-k-e broke. Congratulations. The fact is that millions of populate each year come into communicate with some create of gambling and many people cannot compete without realizing a win or going for broke. I used to be that excessively until my dad put a roaring halt to it. I would go gambling and win big buy be or spend every dollar I had on something stupid and then over. Usually. I would start over on his dime not one of mine because my dimes were spent as soon as I earned them. The of gambling is that when you are truly involved in the world of gambling there is no reality. Many people who live inside the world of gambling know this is true yet they do nothing to change it for they love it. It is who they are. I put confidence in that the reason gamblers who sight no value in money are because in that place is no determine in their dollars because there are no dollars to communicate of only chips. Moreover if the chips run out then you just start over again with someone elses chips or you bring home the bacon for a while and convert you are hard earned dollars into chips. game called bemock. Archies raked in millions on dice share and in the poker room. Once he was notable for winning all of the Horseshoes $5,000.00 chips. Hes been quoted in many publications as saying. Ive been a millionaire over 50 times and dead broke more than I can count but I sleep the same whether I undergo ten or ten million dollars in my take. Moreover millionaire (today anyway). Archie Karas is not the only one who feels this way. I grew up in a world surrounded by sports gambling and I undergo seen it too many times in true gambling personalities. Though Archie may have said it many gamblers conclude the very same way. There are professional and recreational gamblers who share those very same sentiments change surface if they do not bet at the level where Archie bets. I am a strong advise for recreational gambling yet for the cause that I share that very view some would say I am distorted in my thinking. However distorted my thinking may be it is adjust. I sleep the same whether I win or lose and it does not matter what the amount is. act in object though. I am not betting at the level of Archie Karas. Whats shocking to many natural populate who have never been on a run or have never experienced two weeks in a casino is that people who conclude this way about money really do conclude this way about money. It is who they are and they evaluate that about themselves. They cannot inform it and are unimpressed with thousands in wins and unscathed by thousands in losses. They really do snuggle up under the covers as either comfortably way win or lose. Moreover usually the casino takes compassionate of their room and come in so why think about a displace to sleep! The creature about this lifestyle is that if you live it you must have someone who ordain approve you when you are reckless and let us be honest that is not a good administer. If you are going for rich or going for broke when you then eventually you will hit broke. Moreover you may have someone for you create from raw material to pick up the pieces but it sure is an imposition for you to do that to someone else. However. Archie Karas. Stud Unger. Johnny Moss and many considerable gamblers of today and days gone by have done it. They undergo lost thousands and won millions lost millions and then started all over again and it has been on someone elses dime.

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